Publications

01

Melkonian, T. R.; Vuksanovic, N.; Han, L.; Uttke, Z. A.; Silvaggi, N. R.

Toward an Understanding of the Mechanistic Differences Between the Hydroxylating and Desaturating Pyridoxal 5′-Phosphate-Dependent L-Arginine Oxidases.

ChemBioChem 2026, 27 (15), e70488. DOI

02

Smisek, T.; Vuksanovic, N.; Walker, J. N.; Vu, H.; Rivera, D. D.; Fast, W.; Brodbelt, J. S.; Whitman, C. P.

Characterization of Lipidated New Delhi Metallo-beta-lactamase Using Synthetic Nanodiscs.

Biochemistry 2025, 64 (12), 2679–2696. DOI

03

Melkonian, T. R.; Vuksanovic, N.; Person, M. D.; Chen, T. Y.; Chang, W. C.; Allen, K. N.; Whitman, C. P.

Beyond the beta-alpha-beta Fold: Characterization of a SnoaL Domain in the Tautomerase Superfamily.

Biochemistry 2025, 64 (9), 1950–1962. DOI

04

Arbour, C. A.^†; Vuksanovic, N.^†; Allen, K. N.; Imperiali, B.

Dual Glycosyltransferases from Campylobacter concisus Diverge from the Canonical Campylobacter N-Linked Glycan Assembly Pathway.

Biochemistry 2024, 63 (18), 2369–2379. DOI

05

Zhu, X.; Wang, R.; Siitonen, V.; Vuksanovic, N.; Silvaggi, N. R.; Melançon III, C. E.; Metsä-Ketelä, M.

ActVI-ORFA Directs Metabolic Flux Towards Actinorhodin by Preventing Intermediate Degradation.

PLoS ONE 2024, 19 (8), e0308684. DOI

06

Vuksanovic, N.; Clasman, J. R.; Imperiali, B.; Allen, K. N.

Specificity determinants revealed by the structure of glycosyltransferase Campylobacter concisus PglA.

Protein Science 2024, 33 (1), e4848. DOI

07

Arbour, C. A.; Vuksanovic, N.; Bernstein, H. M.; Allen, K. N.; Imperiali, B.

Characterization of PglJ, a Glycosyltransferase in the Campylobacter concisus N-Linked Protein Glycosylation Pathway that Expands Glycan Diversity.

Biochemistry 2024, 63 (1), 141–151. DOI

08

Vuksanovic, N.^†; Melkonian, T. R.^†; Serrano, D. A.; Schwabacher, A. W.; Silvaggi, N. R.

Structural and Biochemical Characterization of MppQ, an L-Enduracididine Biosynthetic Enzyme from Streptomyces hygroscopicus.

Biochemistry 2023, 62 (21), 3105–3115. DOI

09

Majumder, A.; Vuksanovic, N.; Ray, L. C.; Bernstein, H. M.; Allen, K. N.; Imperiali, B.; Straub, J. E.

Synergistic computational and experimental studies of a phosphoglycosyl transferase membrane/ligand ensemble.

Journal of Biological Chemistry 2023, 299 (10), 105194. DOI

10

Melkonian, T. R.^†; Vuksanovic, N.^†; Silvaggi, N. R.

Probing mechanistic questions in the PLP- and O(2)-dependent l-Arg oxidases.

Methods in Enzymology 2023, 685, 493–529. DOI

11

Johnston, N.; Samuels, T. L.; Goetz, C. J.; Arnold, L. A.; Smith, B. C.; Seabloom, D.; Wuertz, B.; Ondrey, F.; Wiedmann, T. S.; Vuksanovic, N.; Silvaggi, N. R.; MacKinnon, A. C.; Miller, J.; Bock, J.; Blumin, J. H.

Oral and Inhaled Fosamprenavir Reverses Pepsin-Induced Damage in a Laryngopharyngeal Reflux Mouse Model.

Laryngoscope 2022, 133 Suppl 1 (Suppl 1), S1–S11. DOI

12

Virdi, R. S.; Bavisotto, R. V.; Hopper, N. C.; Vuksanovic, N.; Melkonian, T. R.; Silvaggi, N. R.; Frick, D. N.

Discovery of Drug-Like Ligands for the Mac1 Domain of SARS-CoV-2 Nsp3.

SLAS Discovery 2020, 25 (10), 1162–1170. DOI

13

Vuksanovic, N.; Zhu, X.; Serrano, D. A.; Siitonen, V.; Metsa-Ketela, M.; Melancon, C. E., 3rd; Silvaggi, N. R.

Structural characterization of three noncanonical NTF2-like superfamily proteins: implications for polyketide biosynthesis.

Acta Crystallographica Section F 2020, 76 (Pt 8), 372–383. DOI

14

Frick, D. N.; Virdi, R. S.; Vuksanovic, N.; Dahal, N.; Silvaggi, N. R.

Molecular Basis for ADP-Ribose Binding to the Mac1 Domain of SARS-CoV-2 nsp3.

Biochemistry 2020, 59 (28), 2608–2615. DOI

15

Han, L.; Vuksanovic, N.; Oehm, S. A.; Fenske, T. G.; Schwabacher, A. W.; Silvaggi, N. R.

Streptomyces wadayamensis MppP is a PLP-Dependent Oxidase, Not an Oxygenase.

Biochemistry 2018, 57 (23), 3252–3264. DOI